Vasopressin Rescue for Pulmonary Hypertension in Neonates
Vasopressin Rescue for Pulmonary Hypertension in Neonates
In summary, this case series suggests that low-dose vasopressin infusion may reverse catecholamine resistance systemic hypotension secondary to severe PPHN and improve oxygenation. The mechanism of action remains unclear but may be delineated through conductance of a pharmacokinetic study. A prospective randomized trial is needed to confirm its efficacy and safety in the management of severe PPHN, before making any recommendation for routine clinical practice.
Conclusions
In summary, this case series suggests that low-dose vasopressin infusion may reverse catecholamine resistance systemic hypotension secondary to severe PPHN and improve oxygenation. The mechanism of action remains unclear but may be delineated through conductance of a pharmacokinetic study. A prospective randomized trial is needed to confirm its efficacy and safety in the management of severe PPHN, before making any recommendation for routine clinical practice.
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