146. Benedict IX (1032 - 1045)
First and only person to be pope more than once (three times, to be specific).

150. Clement II (1046 - 1047)
First person who remained bishop of his previous dioceses even after becoming bishop of Rome as well. Several of his successors followed suit.

158. St. Gregory VII (1073 - 1085)
Gregory decreed that the title "pope" should only be used for the bishop of Rome. Before this every bishop in the West had the title "pope" and in the East it was applied to many priests as well.

159. Blessed Victor III (1086 - 1087)
First pope to be beatified without also subsequently being canonized (this list of popes to whom this has happened is very short).

160. Blessed Urban II (1088 - 1099)
Launched the First Crusade.
Established the Roman Curia to administer the papal court.

168. Blessed Eugene III (1145 - 1153)
The title "Vicar of Christ" finally became attached exclusively to the papacy.
First pope from the Cictercian order.

170. Adrian IV (1154 - 1159)
First (and thus far only) pope from England.

171. Alexander III (1159 - 1181)
First lawyer to be elected pope.

177. Innocent III (1198 - 1216)
Innocent claimed authority over the entire world as well as the universal Christian Church.

186. Blessed Innocent V (1276)
First member of the Dominican order elected pope. Because he kept wearing the Domincans' white cassock, it became traditional papal garb even today.

188. John XXI (1276 - 1277)
John was the first (and only) Portugese pope as well as the only medical doctor to be pope.

192. Nicholas IV (1288 - 1292)
Under Nicholas, Christianity first reached China.

First pope from the Franciscan order.

193. St. Celestine V (1294)
Celestine is well known for having resigned, though he was not the first, last, or only pope to resign. His resignation did, however, lead to the official status for how a pope can resign.

194. Boniface VIII (1294 - 1303)
First pope to proclaim a Holy Year (1300).

210. Callistus III (1455 - 1458)
First of two Spanish popes.

213. Sixtus IV (1471 - 1484)
Named a record six nephews as cardinals.
Had the Sistine Chapel created.

217. Julius II (1503 - 1513)
Patron of Michaelangelo and Raphael, two artists whose work has long outlived Julius'.

219. Adrian VI (1522 - 1523)
First and only Dutch pope.

221. Paul III (1534 - 1549)
Convened the Council of Trent, launching the Counter-Reformation.

224. Paul IV (1555 - 1559)
Established the Index of Forbidden Books.
Segregated Jews to a special quarter of Rome and required them to wear special headgear.

226. St. Pius V (1566 - 1572)
Excommunicated Queen Elizabeth of England.

229. Urban VII (1590)
Shortest pontificate in history.

234. Paul V (1605 - 1621)
Censured Galileo.

235. Gregory XV (1621 - 1623)
Decreed that papal elections proceed by secret ballot.

248. Benedict XIV (1740 - 1758)
First pope to issue an encyclical.

255. Gregory XVI (1831 - 1846)
First and only Camaldosese monk to become pope.

264. John Paul I (1978)
First pope to take a double name.
First pope in more than 1000 years to refuse the traditional crowning ceremony.

265. John Paul II (1978 - 2005)
First non-Italian pope in 455 years.
Most extensively travelled pope.