Ramipril-based vs Diuretic-based Treatment in Pre-diabetes
Ramipril-based vs Diuretic-based Treatment in Pre-diabetes
The present study documents a high incidence rate for type-2 diabetes during the course of a four year observational period. Our key finding is in line with the large prospective randomized studies such as ASCOT-BPLA, VALUE, DREAM and NAVIGATOR and meta-analyses, which reported a significantly reduced incidence of new-onset diabetes with RAS based pharmacotherapy compared to diuretics, beta-blockers or placebo in pre-diabetic, hypertensive or cardiovascular risk patients. Patients at risk for the development of diabetes, who are identified with the PreDisc-Score should preferably be treated first line with ramipril rather than a diuretic or beta blocking agent for arterial hypertension.
Conclusions
The present study documents a high incidence rate for type-2 diabetes during the course of a four year observational period. Our key finding is in line with the large prospective randomized studies such as ASCOT-BPLA, VALUE, DREAM and NAVIGATOR and meta-analyses, which reported a significantly reduced incidence of new-onset diabetes with RAS based pharmacotherapy compared to diuretics, beta-blockers or placebo in pre-diabetic, hypertensive or cardiovascular risk patients. Patients at risk for the development of diabetes, who are identified with the PreDisc-Score should preferably be treated first line with ramipril rather than a diuretic or beta blocking agent for arterial hypertension.
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