New Drug Lowers Levels of Triglyceride Blood Fats: Study
New Drug Lowers Levels of Triglyceride Blood Fats: Study
By Steven Reinberg
HealthDay Reporter
WEDNESDAY, July 29, 2015 (HealthDay News) -- An experimental drug dramatically lowers blood levels of potentially harmful triglycerides, a new study finds.
Triglycerides are a type of blood fat created by the food you eat. At very high levels, they can cause heart problems and pancreatitis, an inflammation of the pancreas.
"Current treatment for elevated triglyceride [levels] leaves a lot to be desired," said researcher Dr. Joseph Witztum, a professor of medicine at the University of California, San Diego. "This drug holds the promise that it will be the most effective therapy we have."
The new drug -- called ISIS 304801 for now -- lowers triglyceride levels by as much as 71 percent without unpleasant side effects, the study found.
Elevated triglycerides can be caused by genetics as well as obesity, smoking, drinking too much alcohol and a diet very high in carbohydrates, the American Heart Association says.
Normal triglyceride levels are less than 150 milligrams per deciliter (mg/dL). But some people have much higher levels, which is associated with insulin resistance, metabolic syndrome, diabetes, inherited high cholesterol and certain other disorders, the researchers explained. Metabolic syndrome is a combination of high blood pressure, high cholesterol, high blood sugar and excess body fat.
A blood test will show levels of LDL ("bad") cholesterol, along with HDL ("good") cholesterol, and one-fifth of your triglyceride level, according to the American Heart Association.
Current treatments for elevated triglycerides include eating a healthy diet rich in fish oil and taking niacin (Niaspan), also called nicotinic acid. Drugs called fibrates, such as TriCor, can help lower triglyceride levels, but some patients don't respond to the usual treatments, Witztum said.
The new drug works by targeting a protein -- called apolipoprotein C-III -- that slows the breakdown of triglycerides. In effect, ISIS 304801 speeds up the breakdown of triglycerides, allowing the fat to leave the body quickly.
"The drug lowers triglyceride and probably manifestations of insulin resistance and metabolic syndrome," Witztum said.
For the study, researchers treated 57 patients with the drug or an inactive placebo. Their triglyceride levels ranged between 350 and 2,000 mg/dL, and they received weekly doses of the drug over 13 weeks.
HealthDay Reporter
WEDNESDAY, July 29, 2015 (HealthDay News) -- An experimental drug dramatically lowers blood levels of potentially harmful triglycerides, a new study finds.
Triglycerides are a type of blood fat created by the food you eat. At very high levels, they can cause heart problems and pancreatitis, an inflammation of the pancreas.
"Current treatment for elevated triglyceride [levels] leaves a lot to be desired," said researcher Dr. Joseph Witztum, a professor of medicine at the University of California, San Diego. "This drug holds the promise that it will be the most effective therapy we have."
The new drug -- called ISIS 304801 for now -- lowers triglyceride levels by as much as 71 percent without unpleasant side effects, the study found.
Elevated triglycerides can be caused by genetics as well as obesity, smoking, drinking too much alcohol and a diet very high in carbohydrates, the American Heart Association says.
Normal triglyceride levels are less than 150 milligrams per deciliter (mg/dL). But some people have much higher levels, which is associated with insulin resistance, metabolic syndrome, diabetes, inherited high cholesterol and certain other disorders, the researchers explained. Metabolic syndrome is a combination of high blood pressure, high cholesterol, high blood sugar and excess body fat.
A blood test will show levels of LDL ("bad") cholesterol, along with HDL ("good") cholesterol, and one-fifth of your triglyceride level, according to the American Heart Association.
Current treatments for elevated triglycerides include eating a healthy diet rich in fish oil and taking niacin (Niaspan), also called nicotinic acid. Drugs called fibrates, such as TriCor, can help lower triglyceride levels, but some patients don't respond to the usual treatments, Witztum said.
The new drug works by targeting a protein -- called apolipoprotein C-III -- that slows the breakdown of triglycerides. In effect, ISIS 304801 speeds up the breakdown of triglycerides, allowing the fat to leave the body quickly.
"The drug lowers triglyceride and probably manifestations of insulin resistance and metabolic syndrome," Witztum said.
For the study, researchers treated 57 patients with the drug or an inactive placebo. Their triglyceride levels ranged between 350 and 2,000 mg/dL, and they received weekly doses of the drug over 13 weeks.
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